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Crossbow Therapeutics’ plans to scale with an integrated operations platform on Kaleidoscope
Case study
Geraldine Paulus
Cofounder, VP of Corp Dev and Ops
Alona Kulesha
Sr. Scientist
Preethi Sankaran
Scientist
Science
Antibody, Oncology
Website
crossbowtx.com

Outcomes

Democratized data access
A systematic and searchable experiment catalog that makes finding key data fast and simple for the whole team
Integrated operations platform
One platform that solves data and project management, spans research and development, and integrates with other tools
Peace of mind and hours saved
Besides cutting hours spent finding data, the team can rest easy with a data strategy that scales with the company

About Crossbow Therapeutics

Crossbow Therapeutics is an oncology therapeutics company focused expanding the reach of antibody-based therapeutics using T-cell receptor (TCR)-mimetic antibodies. Their potent and precise T-Bolt™ therapies are easily assembled immunotherapies directed with high precision at previously unreachable cancer cell targets.

Challenges

Combined data and project management

While each scientist recorded experiments in their individual Benchling entries, as a team Crossbow needed to manage allocation and timelines, coordinate requests across teams, and then index and organize the data in aggregate.

Aggregating data was time consuming

Despite having Benchling and Sharepoint in place, finding and compiling data across the team was manual and time-consuming. As VP of Corporate Development and Operations, Geraldine would need to track down scientists to determine what Benchling entry was the source for a given graph. Updating a deck could take hours or days.

Solutions

Before starting to use Kaleidoscope, Crossbow had data in Benchling and Sharepoint. Scientists would capture experiments in their individual lab notes, but making sense of this data in aggregate was a big challenge. To both organize their growing body of data and become more systematic with team allocation, they needed a better workflow. As VP of Corporate Development and Operations, Geraldine looked for a long term solution. “It’s one thing when you have five scientists, but we wanted to set ourselves up for success as we scale. We wanted to do this the right way.”

“Kaleidoscope is our team’s combined data and project management portal. One central repository where you can find any experiment.”
Geraldine Paulus, Cofounder, VP of Corp Dev and Ops

A working group at Crossbow tested out using Kaleidoscope and soon decided to roll it out to the whole team. “Before Kaleidoscope, it was very difficult to find data independently. I’d have to email scientists and ask what Benchling entry was the source for a graph I’m looking at. I’d probably search for half an hour and then email the scientist, and that could take hours or days.”

Kaleidoscope gave Crossbow the tools to build an organized experiments catalog. Features like experiment types, labels, and filters make it easy for leads to find the right data. The Kaleidoscope team worked with Crossbow to align internally on a label ontology capturing purpose, methodology, program, and functional team. With that foundation, they were able to set up their Kaleidoscope workspace to automatically apply the right labels and ensure a consistent structure for the data.

“Now I can find the exact data I’m looking for myself. The complex search functions with and/or gates to help you find the datasets you want to compare – it’s really powerful. Cumulatively, this makes a big difference in my efficiency every week.”
Geraldine Paulus, Cofounder, VP of Corp Dev and Ops

Crossbow uses Kaleidoscope’s integration with Benchling for a workflow that seamlessly moves between the two tools. Kaleidoscope mirrors your Benchling experiments and lets you Gantt and program manage them, as well as automatically label them for searchability. Alternatively, the team can use Kaleidoscope for detailed experiment requests, then move to Benchling to start the entry, and two are constantly in sync. Having this integrated project management layer in close alignment with their data is important for facilitating streamlined cross team communication at Crossbow.

“It's much easier to use a project management tool like Kaleidoscope to track tasks that need to be communicated between departments. Everyone knows that you’ve started on it, that it’s in progress, and its anticipated date. So people won't email you every day asking if it is done.”
Alona Kulesha, Sr. Scientist

Investing in a long term partnership

Implementing a sustainable data management was mission critical for Crossbow. They considered building their own LIMS system. “We would have had to build for 6-12 months with a LIMS consultant or engineer, whereas with Kaleidoscope, it feels like you’ve helped us build our own tool.”

Your team felt like an extension of our team. You’ve been a part of our data management team and given us the tools we need, tracked our requests and responded quickly – it’s been very helpful.”
Geraldine Paulus, Cofounder, VP of Corp Dev and Ops

Kaleidoscope places heavy emphasis on customer requests and translating them into simple, easy to use software.

“The engineers have been so great! I wanted everyone to be able to use it, so it had to be really convenient for scientists. Usability is super important and you guys really pulled through on that.”
Preethi Sankaran, Scientist

Looking ahead, Crossbow will be moving into the Development part of R&D, as they gear up for their first clinical trial and prepare for IND. “We plan to use Kaleidoscope for tracking those tasks as well so it’s nice to use one tool for both sides of the house. On the research side, I’m excited to use dashboards for updating our CSO and Board to show them program progress at a higher level.”

“It gives me peace of mind that we’re set up for success. I know things aren’t going to fall through the cracks. Experiments are well documented, backed up, and easy to find.”
Geraldine Paulus, Cofounder, VP of Corp Dev and Ops
Kaleidoscope allows the discovery team to make faster and better-informed decisions because they have all the data at their fingertips.
Ewan Taylor
CSO and Co-founder
Kaleidoscope provides the ability to align our key partners, and effectively manage our growing portfolio of IP. It saves us 10 or more hours per week.
Marina Crowe
Chief of Staff
We needed a better system for tracking our R&D data and progress — Kaleidoscope enables more efficient decision making and communication to key stakeholders.
Geraldine Paulus
Co-founder, VP Operations
Kaleidoscope expertly streamlines our data sharing with CROs, making sure Psivant remains in perfect harmony.
Shivam Patel
Head of Data Science & ML
Powerful, intuitive, well-designed ... lets biotechs spend resources on their actual IP: the assets and biology.
Brian Naughton
Co-founder and CTO
We realized that sharing our data in Kaleidoscope was really attractive to Pharma partners – it showed clarity of progress and that we have clean and organized data to work with.
SVP Business Development
Platform Tx company with multi-asset pipeline
Prior to Kaleidoscope it would take me 4-5 steps per workflow to do what I can now achieve in one step. I’m also able to spend 3x less time each week searching for, collating, and navigating data.
Director of Preclinical Operations
Early stage small molecule therapeutics company
Align your team on the big picture